amino_acid
Isoleucine
TL;DR
L-Isoleucine is an essential branched-chain amino acid (BCAA) critical for muscle protein synthesis, hemoglobin production, and blood sugar regulation. It is uniquely capable of stimulating glucose uptake in muscle via PI3K/PKC pathway independently of insulin, making it valuable for metabolic health.
Overview
L-Isoleucine is an essential branched-chain amino acid (BCAA) critical for muscle protein synthesis, hemoglobin production, and blood sugar regulation. It is uniquely capable of stimulating glucose uptake in muscle via PI3K/PKC pathway independently of insulin, making it valuable for metabolic health.
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products in our database contain Isoleucine
Source · MoodStack database
Compound forms
Isoleucine comes in several molecular forms. Each absorbs and acts differently.
L-Isoleucine
(2S,3S)-2-amino-3-methylpentanoic acid
Bioavailability
98%
Typical dose
2–10 g
Benefits
- Muscle protein synthesis
- Blood sugar regulation
- Hemoglobin synthesis
- Immune function
Dose guide
Common dose
1-5 g daily (as part of BCAA blend: 2:1:1 Leu:Iso:Val ratio)
Typical range
1000–5000 mg
Based on 13 products in our database.
Products with Isoleucine
Gorilla Mode EAAs
Optimum Nutrition Instantized BCAA 5000 Powder
PLAY! - IntraWorkout
Nutrimuscle BCAA 2.1.2 Resistance Powder
BCAA 2:1:1 200 Tablets
Nutrimuscle BCAA 4.1.1 Builders Powder
ResveraCel®
Optimum Nutrition Platinum Hydrowhey
BCAA
EAA Essential Amino Acids 300 g
Interactions
synergistic. Isoleucine uniquely stimulates glucose uptake via PI3K while leucine activates mTOR for protein synthesis; combined as BCAAs they provide comprehensive muscle support
competes. All BCAAs including isoleucine compete with tryptophan for LAT1 transporter across the BBB; may reduce brain serotonin synthesis
enhances. Isoleucine independently stimulates glucose uptake into muscle cells; may have additive blood sugar-lowering effects
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Medical disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.