SAMe

Other
TL;DR

S-Adenosylmethionine — the body's principal methyl donor for monoamine neurotransmitter synthesis. Meta-analyses find it more effective than placebo and comparable to tricyclic antidepressants for depression, and it augments SSRI response.

Overview

S-Adenosylmethionine — the body's principal methyl donor for monoamine neurotransmitter synthesis. Meta-analyses find it more effective than placebo and comparable to tricyclic antidepressants for depression, and it augments SSRI response. Can precipitate mania in bipolar disorder; multiple drug interactions; expensive and unstable.
0 of 564
products in our database contain SAMe
Source: StackAura Database

Dosage Guide

Common Dosage

400–1600 mg/day, split, on an empty stomach

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.

Track your supplements and discover what works best for your body and mind. Science-backed insights for optimal health.

Company

Download

Available on iOS. We're currently working on Android. Start tracking your supplements today.

© 2026 MoodStack. All rights reserved.
Made with MoodStack logo for your health.