herb
St. John’s Wort
TL;DR
St. John's Wort (Hypericum perforatum) contains hyperforin and hypericin.
Overview
St. John's Wort (Hypericum perforatum) contains hyperforin and hypericin. It inhibits reuptake of serotonin, norepinephrine, dopamine, GABA, and glutamate. Meta-analyses confirm efficacy equal to SSRIs for mild-moderate depression. CAUTION: Major drug interactions via CYP3A4 induction.
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products in our database contain St. John’s Wort
Source · MoodStack database
Compound forms
St. John’s Wort comes in several molecular forms. Each absorbs and acts differently.
St. John’s Wort
Hypericum perforatum
Bioavailability
25%
Typical dose
300–1800 mg
Benefits
- Antidepressant
- Multiple reuptake inhibition
- Anti-inflammatory
- Wound healing
Dose guide
Common dose
300 mg 3x daily (standardized to 0.3% hypericin)
Typical range
300–900 mg
Based on 0 products in our database.
Interactions
dangerous. St. John's Wort inhibits serotonin, norepinephrine, and dopamine reuptake; combining with pharmaceutical antidepressants can cause serotonin syndrome (hyperthermia, seizures, death)
inhibits. St. John's Wort strongly induces CYP3A4 and P-glycoprotein, significantly reducing blood levels of ethinyl estradiol and progestins; documented contraceptive failures
inhibits. Potent CYP3A4 induction reduces cyclosporine levels by 40-60%; documented cases of organ transplant rejection due to this interaction
inhibits. CYP induction increases warfarin metabolism, reducing its anticoagulant effect; INR may drop significantly, increasing thrombotic risk
synergistic. Both support mood through complementary mechanisms — SJW modulates monoamine reuptake while omega-3 DHA supports neuronal membrane fluidity for neurotransmitter signaling
Related categories
Medical disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.