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  3. Caffeine vs Alpha-GPC

Caffeine vs Alpha-GPC

TL;DR

Quick comparison: Caffeine and Alpha-GPC have 1 overlapping categories and appear together in 10 products.

  • •Choose Caffeine if: Caffeine boosts alertness and focus by stimulating the central nervous system, e...
  • •Choose Alpha-GPC if: Alpha-glycerylphosphorylcholine (Alpha-GPC) is the most bioavailable choline sou...
  • •Take both if: You want comprehensive coverage across 1 shared categories.
564 products
analyzed in our comprehensive supplement database
Source: MoodStack Database (2026)

Side-by-Side Comparison

FeatureCaffeineAlpha-GPC
Typealkaloidother
Common DosageN/A300-1200 mg daily
Best BioavailabilityCaffeine Anhydrous (99%)N/A
Categories32
Available Products00

Caffeine

Typealkaloid
Common DosageN/A
Best BioavailabilityCaffeine Anhydrous (99%)
Categories3
Available Products0

Alpha-GPC

Typeother
Common Dosage300-1200 mg daily
Best BioavailabilityN/A
Categories2
Available Products0

Can You Take Both?

Yes, Caffeine and Alpha-GPC can typically be taken together. In fact, we found 10 products in our database that contain both supplements, suggesting they complement each other well.

Both supplements share 1 common category, indicating they may work synergistically for similar health goals.

Key Differences

Caffeine

Caffeine boosts alertness and focus by stimulating the central nervous system, enhances physical performance, and may improve mood. It supports metabolism and fat burning, potentially aiding weight management. Coffee, tea, and energy drinks are common sources.

Categories:

Fat LossEnduranceFocus & Cognition

Common Forms:

  • • Caffeine Anhydrous (99% bioavailability)
  • • Di-Caffeine Malate (95% bioavailability)
  • • Caffeine (as Green Coffee Bean Extract) (70% bioavailability)

Alpha-GPC

Alpha-glycerylphosphorylcholine (Alpha-GPC) is the most bioavailable choline source for the brain, crossing the BBB to directly increase acetylcholine synthesis. It also stimulates growth hormone release. Used clinically in Europe for cognitive decline (as Gliatilin/Delecit).

Categories:

BiohackingFocus & Cognition

Shared Categories

Both Caffeine and Alpha-GPC are used for these health goals:

🧠Focus & Cognition

Products Containing Both Caffeine and Alpha-GPC

We found 12 products that combine both supplements:

Transparent Labs BULK Pre-Workout

Transparent Labs BULK Pre-Workout

Transparent Labs

$49.99Score: 93/100
Transparent Labs BULK Pre-Workout

Transparent Labs BULK Pre-Workout

Transparent Labs

$49.99Score: 93/100
Gorilla Mode Lightning

Gorilla Mode Lightning

Gorilla Mind

$64.99Score: 91/100
Transparent Labs BULK Black Pre-Workout

Transparent Labs BULK Black Pre-Workout

Transparent Labs

$54.99Score: 88/100
Gorilla Mind Nootropic

Gorilla Mind Nootropic

Gorilla Mind

$49.99Score: 88/100
Gorilla Mind Energy Drink

Gorilla Mind Energy Drink

Gorilla Mind

$34.99Score: 88/100
Transparent Labs BULK Black Pre-Workout

Transparent Labs BULK Black Pre-Workout

Transparent Labs

$54.99Score: 88/100
Gorilla Mode Base Pre-Workout

Gorilla Mode Base Pre-Workout

Gorilla Mind

$21.99Score: 87/100
Gorilla Mind Respawn

Gorilla Mind Respawn

Gorilla Mind

$59.99Score: 87/100
Gorilla Mind Energy Shot

Gorilla Mind Energy Shot

Gorilla Mind

$29.99Score: 87/100
Gorilla Mind Rush

Gorilla Mind Rush

Gorilla Mind

$49.99Score: 85/100

GHOST Energy Drink

GHOST

$29.99Score: 79/100

Frequently Asked Questions

What is the difference between Caffeine and Alpha-GPC?

Caffeine and Alpha-GPC are both important supplements with distinct properties. Caffeine Caffeine boosts alertness and focus by stimulating the central nervous system, enhances physical performance, and may improve mood. It supports metabolism and fat burning, potentially aiding weight management. Coffee, tea, and energy drinks are common sources., while Alpha-GPC Alpha-glycerylphosphorylcholine (Alpha-GPC) is the most bioavailable choline source for the brain, crossing the BBB to directly increase acetylcholine synthesis. It also stimulates growth hormone release. Used clinically in Europe for cognitive decline (as Gliatilin/Delecit)..

Can I take Caffeine and Alpha-GPC together?

Based on our analysis of 10 products that contain both, yes, Caffeine and Alpha-GPC can typically be taken together. However, always consult with a healthcare provider before combining supplements.

Which is more popular: Caffeine or Alpha-GPC?

In our database of 564 products, Caffeine appears in 49 products, while Alpha-GPC appears in 13 products.

Related Comparisons & Products

What is Caffeine?What is Alpha-GPC?Alpha-GPC vs Ginkgo BilobaAlpha-GPC vs SaffronL-Tyrosine vs CaffeineTransparent Labs BULK Pre-Workout (contains both)Transparent Labs BULK Pre-Workout (contains both)Gorilla Mode Lightning (contains both)

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.