vitamin
Folate
TL;DR
Folate (vitamin B9) is essential for DNA synthesis, methylation, and cell division. It is critical during pregnancy for neural tube development.
Overview
Folate (vitamin B9) is essential for DNA synthesis, methylation, and cell division. It is critical during pregnancy for neural tube development. Supplemental forms include folic acid (synthetic), methylfolate (5-MTHF, active form), and folinic acid. MTHFR gene variants affect folate metabolism in ~40% of the population.
23 / 565
products in our database contain Folate
Source · MoodStack database
Compound forms
Folate comes in several molecular forms. Each absorbs and acts differently.
Calcium L-5 Methyltetrahydrofolate
Bioavailability
85%
Typical dose
100–400 mcg
L-MTHF
Bioavailability
85%
Typical dose
—
Benefits
- DNA synthesis
- Neural tube defect prevention
- Homocysteine regulation
- Methylation support
- Mood regulation
Dose guide
Common dose
400-1000 mcg daily (prefer methylfolate for MTHFR variants)
Typical range
400–1000 mcg
Based on 23 products in our database.
Products with Folate
Transparent Labs Cognition Nootropic
Brain Drive
Longevity
Transparent Labs Dopamine+
Transparent Labs Multivitamin
Essential Capsules
Essential Multivitamin
Iron+
Transparent Labs PUMP Pre-Workout
USDA Organic Multivitamin
Interactions
synergistic. B12 regenerates tetrahydrofolate from methylTHF via methionine synthase; without B12, folate is trapped and cannot function properly (methyl trap)
synergistic. Zinc is a cofactor for folate conjugase that releases food folate for absorption; zinc deficiency impairs folate bioavailability
competes. Methotrexate is a folate antagonist; folic acid reduces MTX side effects but may reduce cancer treatment efficacy
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Medical disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.