herb
Valerian
TL;DR
Valerian (Valeriana officinalis) is a sedative herb whose active compounds (valerenic acid, isovaleric acid, GABA, and iridoids) interact with GABA-A and 5-HT5a receptors. German Commission E and WHO approve it for insomnia and restlessness.
Overview
Valerian (Valeriana officinalis) is a sedative herb whose active compounds (valerenic acid, isovaleric acid, GABA, and iridoids) interact with GABA-A and 5-HT5a receptors. German Commission E and WHO approve it for insomnia and restlessness. Effects improve with continued use over 2-4 weeks.
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products in our database contain Valerian
Source · MoodStack database
Compound forms
Valerian comes in several molecular forms. Each absorbs and acts differently.
Valerian
Valeriana officinalis
Bioavailability
20%
Typical dose
300–2000 mg
Benefits
- Sleep improvement
- GABA modulation
- Anxiolytic
- Muscle relaxation
Dose guide
Common dose
300-600 mg extract 30-60 minutes before bed
Typical range
300–600 mg
Based on 3 products in our database.
Products with Valerian
Interactions
synergistic. Valerian increases GABA via inhibiting GABA transaminase while magnesium blocks excitatory NMDA receptors and supports GABA signaling; complementary sleep mechanisms
synergistic. Valerian promotes sleep via GABA enhancement while melatonin signals circadian sleep timing; different mechanisms for sleep initiation
enhances. Valerian's GABAergic activity potentiates sedative effects of benzodiazepines, barbiturates, and alcohol; risk of excessive CNS depression
synergistic. Valerian promotes GABA-mediated relaxation while L-Theanine promotes alpha brain waves; complementary calming effects
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Medical disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.