Aids and relaxants to improve sleep quality and duration.
Top picks for Sleep supplements based on scientific evidence and product analysis.
Essential mineral involved in over 300 enzymatic reactions including energy production, protein synthesis, muscle/nerve function, and blood pressure regulation.
Benefits: Supports muscle and nerve function, Essential for energy production, May improve sleep quality, Supports bone health, May reduce anxiety and stress, Important for blood pressure regulation
Found in 82 products
L-Theanine promotes relaxation without drowsiness, reduces stress, and improves focus when paired with caffeine. It supports sleep quality and enhances alpha brain wave activity. Found in green tea and supplements.
Benefits: Promotes relaxation, reduces stress, and improves focus.
Found in 26 products
Hormone produced by pineal gland that regulates circadian rhythm.
Benefits: Supports healthy sleep onset, Helps regulate circadian rhythm, May help with jet lag, Has antioxidant properties, May support immune function
Found in 9 products
L-Tryptophan is an essential amino acid and the sole precursor to serotonin (via 5-HTP) and melatonin. It has the lowest plasma concentration of all amino acids, making it rate-limiting for serotonin synthesis. Competes with other large neutral amino acids (BCAAs) for BBB transport; carbohydrate intake enhances brain uptake.
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Found in 7 products
L-Glycine supports sleep quality, reduces stress, and aids collagen synthesis for healthy skin and joints. It acts as a neurotransmitter, promoting cognitive function. Found in meat, dairy, and supplements.
Benefits: Supports sleep quality, cognitive function, and joint health.
Found in 6 products
Reishi (Ganoderma lucidum), the "Mushroom of Immortality," has been used in East Asian medicine for 2,000+ years. Active compounds include ganoderic acids (triterpenes), beta-glucan polysaccharides, and germanium. One of the most well-researched medicinal mushrooms, with over 400 bioactive compounds identified.
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Found in 3 products
Valerian (Valeriana officinalis) is a sedative herb whose active compounds (valerenic acid, isovaleric acid, GABA, and iridoids) interact with GABA-A and 5-HT5a receptors. German Commission E and WHO approve it for insomnia and restlessness. Effects improve with continued use over 2-4 weeks.
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Found in 3 products
Lemon balm (Melissa officinalis) is a calming herb from the mint family with GABAergic and serotonergic activity. Active compounds include rosmarinic acid, eugenol, and citral. Clinical trials demonstrate anxiolytic, cognitive-enhancing, and sleep-promoting effects. Often combined with valerian for synergistic calming.
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Found in 2 products
Passionflower (Passiflora incarnata) is a GABAergic anxiolytic herb with clinical evidence comparable to benzodiazepines for anxiety without sedation or cognitive impairment. Active compounds include chrysin, vitexin, and GABA itself.
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Found in 1 products
Apigenin is a flavonoid abundant in chamomile, parsley, and celery. It binds to GABA-A benzodiazepine receptors for anxiolytic effects, inhibits CD38 to increase NAD+, and has senolytic properties. One of Dr. Andrew Huberman's most-recommended sleep and longevity compounds.
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Found in 1 products
Chamomile (Matricaria chamomilla) is one of the oldest and most widely used medicinal herbs. Its active compounds include apigenin (a potent anxiolytic that binds GABA-A benzodiazepine receptors), chamazulene, and bisabolol. Clinically validated for anxiety, sleep, and digestive support.
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Found in 1 products
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.
