Senolytic, NAD+ boosting, and cellular rejuvenation compounds for biological age reversal
Top picks for Anti-Aging supplements based on scientific evidence and product analysis.
Vitamin C boosts immunity, promotes collagen production for healthy skin, and enhances iron absorption. As a powerful antioxidant, it helps protect cells from damage and speeds up wound healing. Citrus fruits and supplements are great sources.
Benefits: Enhances collagen synthesis
Found in 109 products
Essential polyunsaturated fatty acids (EPA and DHA) critical for brain function, inflammation regulation, and cardiovascular health.
Benefits: Supports cardiovascular health, Essential for brain function, Has anti-inflammatory effects, Supports eye health, May improve mood and depression, Important for fetal brain development
Found in 33 products
Collagen supports skin elasticity, reduces wrinkles, and strengthens hair and nails. It promotes joint health, improves bone density, and aids gut health. Found in bone broth, fish, and supplements.
Benefits: Supports skin, hair, and joint health
Found in 24 products
Astragalus membranaceus (Huang Qi) is a foundational herb in Traditional Chinese Medicine used for over 2,000 years. It contains active compounds including astragalosides, polysaccharides, and flavonoids. Research highlights its immunomodulatory, anti-aging (telomerase activation), and cardioprotective properties.
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Found in 4 products
Ubiquinol is the reduced (active) form of Coenzyme Q10, with 3-6x greater bioavailability than ubiquinone. It is essential for mitochondrial ATP production (electron transport chain) and is the body's most potent lipid-soluble antioxidant. Production declines with age and statin use. Heart, brain, and kidneys have highest requirements.
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Found in 3 products
Resveratrol is a polyphenol stilbene found in red grape skin, Japanese knotweed, and berries. It activates SIRT1 (the longevity sirtuin), AMPK, and Nrf2 pathways. Despite bioavailability challenges, clinical evidence supports cardiovascular, metabolic, and neuroprotective effects. Trans-resveratrol is the bioactive form.
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Found in 3 products
Glutathione (GSH) is the body's master antioxidant, a tripeptide of cysteine, glutamic acid, and glycine. It is central to detoxification (Phase II conjugation), immune function, and cellular protection. Liposomal and reduced (GSH) forms have improved bioavailability over standard oral glutathione.
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Found in 3 products
Nicotinamide riboside (NR) is a form of vitamin B3 and the most efficient oral precursor to NAD+ (nicotinamide adenine dinucleotide). NAD+ declines 50% between ages 40-60, driving aging and metabolic dysfunction. NR uniquely enters cells via NRK1/2 pathway, bypassing rate-limiting enzymes. Patented as Niagen.
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Found in 2 products
Quercetin is the most abundant dietary flavonoid, found in onions, apples, and berries. It is a potent antioxidant, senolytic, and mast cell stabilizer. Combined with dasatinib, it forms the most studied senolytic protocol. Also demonstrates significant anti-inflammatory, antihistamine, and cardiovascular benefits.
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Found in 2 products
Pyrroloquinoline quinone (PQQ) is a novel vitamin-like compound that stimulates mitochondrial biogenesis (the creation of NEW mitochondria) — a function unique among supplements. It also activates PGC-1alpha and Nrf2 pathways. Found in natto, parsley, and human breast milk.
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Found in 1 products
Methylene blue (methylthioninium chloride) is a mitochondrial enhancer and redox cycling agent that can both donate and accept electrons in the mitochondrial electron transport chain. At low (hormetic) doses, it enhances mitochondrial function, increases ATP, and demonstrates remarkable neuroprotective effects.
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Found in 1 products
Apigenin is a flavonoid abundant in chamomile, parsley, and celery. It binds to GABA-A benzodiazepine receptors for anxiolytic effects, inhibits CD38 to increase NAD+, and has senolytic properties. One of Dr. Andrew Huberman's most-recommended sleep and longevity compounds.
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Found in 1 products
Spermidine is a polyamine compound involved in cellular processes, including cell growth and function.
Benefits: Potential longevity enhancement, Cellular autophagy promotion
Found in 1 products
Fisetin is a flavonoid found in strawberries, apples, and persimmons. It has emerged as the most potent natural senolytic compound (clearing senescent "zombie" cells). Research from the Mayo Clinic and Salk Institute demonstrates remarkable anti-aging, neuroprotective, and anti-cancer properties.
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Found in 1 products
L-Carnosine is a dipeptide of beta-alanine and histidine concentrated in muscle and brain tissue. It is a powerful intracellular buffer, antioxidant, and anti-glycation agent. Research highlights its role in longevity, protecting against advanced glycation end-products (AGEs), and maintaining muscle function during aging.
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Found in 0 products
For a comprehensive anti-aging stack, combine Resveratrol + NR to target NAD+ and sirtuin pathways simultaneously. Add Ubiquinol + PQQ for mitochondrial support — CoQ10 optimizes existing mitochondria while PQQ creates new ones.
For visible skin anti-aging, pair Collagen (10g) + Vitamin C (500mg) — Vitamin C is required for collagen synthesis. Take collagen on an empty stomach for best absorption.
Important: Fat-soluble supplements (Ubiquinol, Resveratrol) should be taken with meals containing healthy fats for 2-3x better absorption.
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any supplement regimen.
