Best Other Supplements

Creatine monohydrate boosts muscle strength, power, and exercise performance by increasing ATP production. It supports muscle growth, enhances recovery, and may improve cognitive function. Found in red meat and widely used as a supplement.

Alpha-glycerylphosphorylcholine (Alpha-GPC) is the most bioavailable choline source for the brain, crossing the BBB to directly increase acetylcholine synthesis. It also stimulates growth hormone release. Used clinically in Europe for cognitive decline (as Gliatilin/Delecit).

Oil derived from fatty fish rich in omega-3 fatty acids EPA and DHA. Supports heart, brain, and joint health.

Lutein is a carotenoid and a type of pigment found in many plants. It is often known for its role in maintaining eye health, as it helps filter harmful blue light and prevent oxidative damage.

Omega-3 fatty acids (EPA, DHA) support heart health by lowering triglycerides and reducing inflammation. They promote brain function, improve mood, and may lower dementia risk. Found in fatty fish, flaxseeds, and supplements.

Hormone produced by pineal gland that regulates circadian rhythm.

Glucosamine sulfate is an amino sugar naturally produced in the body as a building block for cartilage, tendons, and ligaments. It stimulates chondrocyte production of glycosaminoglycans and proteoglycans. The sulfate form has the strongest clinical evidence, with studies showing it slows structural joint degradation.

Choline is an essential nutrient (recognized by IOM in 1998) critical for brain development, liver function, and methylation. It is the precursor to acetylcholine (the learning neurotransmitter) and phosphatidylcholine (cell membranes). Over 90% of Americans are deficient. Key forms include Alpha-GPC, CDP-Choline, and choline bitartrate.

Ubiquinone-10 (CoQ10/coenzyme Q10) is the oxidized form of Coenzyme Q10. While it must be converted to ubiquinol for antioxidant function, it is the more shelf-stable and affordable form. Both forms are interconverted in the body. Essential for cellular energy production and antioxidant defense.

Lycopene is a carotenoid pigment responsible for the red color in tomatoes and other fruits. It is known for its antioxidant properties and is believed to contribute to health benefits like cardiovascular support and cancer prevention.

Hyaluronic acid (HA) is a glycosaminoglycan naturally present in skin, joints, and eyes. It can hold 1,000x its weight in water, making it essential for tissue hydration. Oral supplementation (high molecular weight) reaches skin and joints; clinical evidence supports benefits for skin hydration, wrinkle reduction, and joint comfort.

Inositol supports mental health by aiding neurotransmitter signaling, reducing anxiety, and improving mood. It enhances insulin sensitivity, supporting metabolic health, and may alleviate PCOS symptoms. Found in fruits, grains, and supplements.

Diindolylmethane (DIM) is a compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. It modulates estrogen metabolism, shifting it toward protective 2-hydroxyestrone metabolites instead of harmful 16-alpha-hydroxyestrone and 4-hydroxyestrone.

Phosphatidylserine (PS) is a phospholipid critical for brain cell membrane structure and function. It is the only brain supplement with a qualified FDA health claim for cognitive function. It modulates cortisol, supports neurotransmitter release, and enhances signal transduction.

Naturally occurring antioxidant involved in cellular energy production. Supports heart health, blood pressure management, and mitochondrial function.

Dietary fiber promotes digestive health, prevents constipation, and supports gut microbiota. It helps regulate blood sugar, lowers cholesterol, and aids weight management by increasing satiety. Fruits, vegetables, and whole grains are excellent sources.

Ubiquinol is the reduced (active) form of Coenzyme Q10, with 3-6x greater bioavailability than ubiquinone. It is essential for mitochondrial ATP production (electron transport chain) and is the body's most potent lipid-soluble antioxidant. Production declines with age and statin use. Heart, brain, and kidneys have highest requirements.

Alpha-lipoic acid (ALA) is a sulfur-containing fatty acid and potent antioxidant naturally found in mitochondria. It is both water- and fat-soluble, allowing it to work throughout the body. Supports glucose metabolism, neuroprotection, and regeneration of other antioxidants like glutathione and vitamin C.

Methylsulfonylmethane — organic sulfur compound supporting joint and cartilage health, inflammation reduction, and connective tissue.

Apigenin is a flavonoid abundant in chamomile, parsley, and celery. It binds to GABA-A benzodiazepine receptors for anxiolytic effects, inhibits CD38 to increase NAD+, and has senolytic properties. One of Dr. Andrew Huberman's most-recommended sleep and longevity compounds.

Fermented apple juice containing acetic acid. Used traditionally for digestive health, blood sugar support, and weight management.

Phytoestrogens found in soybeans that may support hormonal health and bone density.

Medium-chain triglycerides derived from coconut oil. Rapidly absorbed for quick energy and cognitive support.

L-Tartrate is an organic acid salt form used to improve solubility and absorption of minerals and amino acids in supplement formulations.

Tauroursodeoxycholic acid (TUDCA) is a water-soluble bile acid found naturally in small quantities in human bile. It is a potent chemical chaperone that reduces endoplasmic reticulum (ER) stress and protects cells from apoptosis. Used clinically for cholestatic liver diseases and emerging as a powerful cytoprotective agent.

Spermidine is a polyamine compound involved in cellular processes, including cell growth and function.

Broccoli seed extract is the richest source of sulforaphane (via glucoraphanin/myrosinase), one of the most potent activators of the Nrf2 antioxidant pathway. Nrf2 activation upregulates over 200 cytoprotective genes. Research supports cancer prevention, detoxification, and neuroprotective effects.

Glucuronolactone is a naturally occurring metabolite produced in the liver from glucose. It is commonly found in energy drinks (Red Bull contains 600mg). It participates in detoxification (glucuronidation) and connective tissue synthesis. Despite widespread use, human research is limited.

Royal jelly is a nutrient-rich secretion produced by worker honey bees to feed the queen bee. It contains a complex mixture of proteins, sugars, fatty acids (especially 10-HDA), vitamins, and minerals. Traditionally used to support vitality, immune function, and energy levels.

Coconut water is the clear liquid from young green coconuts, naturally rich in electrolytes (potassium, sodium, magnesium). It serves as a natural isotonic beverage for hydration. In supplements, it appears as coconut water powder for electrolyte and mineral content.

Fisetin is a flavonoid found in strawberries, apples, and persimmons. It has emerged as the most potent natural senolytic compound (clearing senescent "zombie" cells). Research from the Mayo Clinic and Salk Institute demonstrates remarkable anti-aging, neuroprotective, and anti-cancer properties.

Methylene blue (methylthioninium chloride) is a mitochondrial enhancer and redox cycling agent that can both donate and accept electrons in the mitochondrial electron transport chain. At low (hormetic) doses, it enhances mitochondrial function, increases ATP, and demonstrates remarkable neuroprotective effects.

Luteolin is a flavonoid found in celery, parsley, broccoli, and chamomile. It is one of the most potent natural mast cell stabilizers and neuroprotective flavonoids. Research highlights anti-neuroinflammatory, anti-allergic, and anti-cancer properties. Increasingly studied for brain fog and neuroinflammation.

Pyrroloquinoline quinone (PQQ) is a novel vitamin-like compound that stimulates mitochondrial biogenesis (the creation of NEW mitochondria) — a function unique among supplements. It also activates PGC-1alpha and Nrf2 pathways. Found in natto, parsley, and human breast milk.

Nicotinamide mononucleotide (NMN) is a precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and longevity pathways. NAD+ levels naturally decline with age.

Cocoa, rich in flavonoids, supports heart health by improving blood flow and lowering blood pressure. It enhances mood, boosts cognitive function, and provides antioxidants to reduce inflammation. Found in dark chocolate and cocoa powder.